A high affinity ligand for the retinoid X receptor (RXR). Destabilizes VDR-RXR heterodimer-DNA complex.
Product Details
| Alternative Name: | Alitretinoin |
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| Formula: | C20H28O2 |
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| MW: | 300.4 |
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| CAS: | 5300-03-8 |
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| Purity: | ≥98% (UHPLC) |
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| Appearance: | Light yellow to orange crystalline powder. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Store tightly sealed in dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers: B. Cheskis & L. P. Freedman; Mol. Cell. Biol.
14, 3329 (1994),
Abstract;
Full Text
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids: G. Allenby, et al.; Proc. Natl. Acad. Sci. USA
90, 30 (1993),
Abstract;
Full Text
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor: R. A. Heyman, et al.; Cell
68, 397 (1992),
Abstract;
9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha: A. A. Levin, et al.; Nature
355, 359 (1992),
Abstract;
