Replaces Prod. #: ALX-350-035
Isotetrandrine is a biscoclaurine alkaloid which inhibits G-protein mediated activation of phospholipase A2 (PLA2) but not phospholipase C (PLC) or D (PLD). Cell permeable.
Product Details
| Alternative Name: | Berbamine methyl ether, 6,6',7,12-Tetramethoxy-2,2'-dimethyl-berbaman |
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| Formula: | C38H42N2O6 |
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| MW: | 622.7 |
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| CAS: | 477-57-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (20mg/ml) or ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes: D. Chan, et al.; Mol. Biol. Cell.
15, 1871 (2004),
Abstract;
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol.
44, 45 (1992),
Abstract;
Tetrandrine and isotetrandrine, two bisbenzyltetrahydroisoquinoline alkaloids from Menispermaceae, with rat uterine smooth muscle relaxant activity: P. D'Ocón, et al.; J. Pharm. Pharmacol.
44, 579 (1992),
Application(s): inhibition of uterine contraction,
Abstract;
Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets: T. Hashizume, et al.; Biochem. Pharmacol.
41, 419 (1991),
Abstract;
Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine: Y. Inubushi, et al.; Tetrahedron Lett.
30, 3399 (1968),
Abstract;
