Replaces Prod. #: ALX-165-001
Selective, competitive and reversible G-protein antagonist. Inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptors (mAChR) and Gs by β-adrenergic receptors in reconstituted phospholipid vesicles. Inhibition is reversible and competitive with respect to receptor binding to G proteins. Substance P (Prod. No. ALX-167-003) related compound.
Product Details
| Alternative Name: | G-protein antagonist 2 |
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| Sequence: | H-Pyr-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 |
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| Formula: | C57H64N12O9S |
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| MW: | 1093.3 |
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| Source: | Synthetic. |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding: H. Mukai, et al.; J. Biol. Chem.
267, 16237 (1992),
Abstract;
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