Replaces Prod. #: ALX-162-001
Cell permeable, amphiphilic, mast cell degranulating tetradecapeptide. Stimulates glycogenolysis and phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes. Directly activates G proteins by a mechanism analogous to that of G protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Stimulates exocytosis and phosphoinositide breakdown in a variety of cells. Inhibits calmodulin, and activates PLA2. Acts as a mitogen in Swiss 3T3 cells and stimulates pertussis toxin-sensitive arachidonate release without phosphoinositide breakdown.
Product Details
| Sequence: | H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2 |
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| Formula: | C70H131N19O15 |
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| MW: | 1478.9 |
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| Source: | Synthetic. Originally isolated from wasp venom (Vespula lewisii). |
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| CAS: | 72093-21-1 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (1 mg/ml) or 100% ethanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci.
7, 501 (2006), Review,
Abstract;
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol.
174, 4252 (2005),
Abstract;
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem.
278, 12039 (2003),
Abstract;
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol.
121, 1406 (1997),
Abstract;
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta
1027, 185 (1990),
Abstract;
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett.
260, 179 (1990),
Abstract;
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem.
263, 6491 (1988),
Abstract;
Full Text
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull.
27, 1942 (1979),
Abstract;
