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Lovastatin . sodium salt

Active in whole cells as well as cell-free assays
BML-G245-0005 5 mg 95.00 USD
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Replaces Prod. #: ALX-430-103

Active carboxylate form of Lovastatin (Prod. No. BML-G226). Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase.

Product Details

Alternative Name:Mevinolin . sodium salt, 6-α-Methylcompactin . sodium salt
Formula:C24H37O6 . Na
MI:14: 5586
Purity:≥97% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (10mg/ml) or 100% ethanol (10mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Cell cycle-specific effects of lovastatin: M. Jakobisiak, et al.; Proc Natl Acad Sci USA 88, 3628 (1991), Abstract;
Inhibition of growth factor signaling pathways by lovastatin: T.S. Vincent, et al.; Biochem. Biophys. Res. Commun. 180, 1284 (1991), Abstract;
Lovastatin blocks N-ras oncogene-induced neuronal differentiation: C.E. Mendola & J.M. Backer; Cell Growth Differ. 1, 499 (1990), Abstract;
All ras proteins are polyisoprenylated but only some are palmitoylated: J.F. Hancock, et al.; Cell 57, 1167 (1989), Abstract;