Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


HMG-CoA reductase inhibitor
BML-G244-0050 50 mg 165.00 USD
BML-G244-0250 250 mg 699.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-430-104

HMG-CoA reductase inhibitor. Synthetic analog of Lovastatin (Prod. No. BML-G226). Inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signalling pathway.

Product Details

MI:14: 8539
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications: H.A. Rather, et al.; Biomater. Biosyst. 8, 100064 (2022), Abstract;
Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer’s disease: X.K. Tong, et al.; Cell Death Dis. 13, 325 (2022), Abstract;
Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation: L. Voss, et al.; Pharmaceuticals (Basel) 14, 727 (2021), Abstract;
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters: M. Mehibel, et al.; Sci. Rep. 8, 16804 (2018), Abstract; Full Text
Simvastatin prevents β-amyloid 25-35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate: C. Wang, et al.; Neuropharmacology 97, 122 (2015), Application(s): Oral administration to male mice, Abstract;
Beyond lipid lowering: the anti-hypertensive role of statins: V. Chopra, et al.; Cardiovasc. Drugs Ther. 21, 161 (2007), Abstract;
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury: H. Wang, et al.; Exp. Neurol. 206, 59 (2007), Abstract;
HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation: H. Xu, et al.; Am. J. Physiol. Renal Physiol. 291, F995 (2006), Abstract;
Anti-inflammatory and immunomodulatory effects of statins: L.M. Blanco-Colio, et al.; Kidney Int. 63, 12 (2003), Abstract;
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy: F.R. Danesh, et al.; Proc Natl Acad Sci USA 99, 8301 (2002), Abstract;
Lovastatin and simvastatin are modulators of the proteasome: C. Wojcik, et al.; Int. J. Biochem. Cell Biol. 32, 957 (2000), Abstract;

Product Toolbox


Certificate of Analysis


By target:
HMG-CoA reductase
By biological activity:
HMG-CoA reductase Inhibitor
By catalog section:


Technical Service
Customer Service