A potent and selective, cell-permeable farnesyl transferase inhibitor IC50=21 nM, 30-fold selective over geranylgeranyl transferase.
Product Details
| Formula: | C22H38N4O3S2 |
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| MW: | 470.7 |
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| CAS: | 149759-96-6 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by ESI-MS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (5mg/ml) or water (2mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation: A. D. Cox, et al.; J. Biol. Chem.
269, 19203 (1994),
Abstract;
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Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: M. A. Garcia, et al.; J. Biol. Chem.
268, 18415 (1993),
Abstract;
Full Text
