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United States 

Chaetomellic acid A

Farnesyltransferase inhibitor
BML-G229-0005 5 mg 81.00 USD
BML-G229-0025 25 mg 330.00 USD
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Replaces Prod. #: ALX-270-064

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

Product Details

Formula:C19H32O4 . 2Na
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in warm water (2mg/ml, slightly cloudy).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Inhibitors of Ras farnesyltransferases.: F. Tamanoi; Trends Biochem. Sci. 18, 349 (1993), Abstract;
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.: J.B. Gibbs, et al.; J. Biol. Chem. 268, 7617 (1993), Abstract;