Replaces Prod. #: ALX-270-064
Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).
Product Details
| Formula: | C19H32O4 . 2Na |
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| MW: | 370.4 |
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| Source: | Synthetic. |
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| CAS: | 148796-51-4 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | >315°C |
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| Solubility: | Soluble in warm water (2mg/ml, slightly cloudy). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of Ras farnesyltransferases.: F. Tamanoi; Trends Biochem. Sci.
18, 349 (1993),
Abstract;
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.: J.B. Gibbs, et al.; J. Biol. Chem.
268, 7617 (1993),
Abstract;
