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α-Hydroxyfarnesylphosphonic acid

Farnesyltransferase inhibitor
BML-G228-0001 1 mg 185.00 USD
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Replaces Prod. #: ALX-290-009

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=30 nM) and in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=35.8 µM and 67 µM respectively). α-Hydroxyfarnesylphosphonic acid inhibited (1 µM) Ras processing in Ha-ras-transformed NIH 3T3 fibroblasts.

Product Details

Concentration:2 mg/ml
Formulation:Solution in ethanol.
Purity:≥98% (TLC)
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
Handling:Do not evaporate to dryness. Compound decomposes out of solution.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Inhibitors of Ras farnesyltransferases: F. Tamanoi; Trends Biochem. Sci. 18, 349 (1993), Abstract;
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo: J.B. Gibbs, et al.; J. Biol. Chem. 268, 7617 (1993), Abstract;
Steady-state kinetic mechanism of Ras farnesyl:protein transferase: D.L. Pompliano, et al.; Biochemistry 31, 3800 (1992), Abstract;