Inhibits cholesterol/isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase. Induces apoptosis in cancer cells.
Product Details
| Alternative Name: | Mevinolin, 6-α-Methylcompactin |
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| Formula: | C24H36O5 |
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| MW: | 404.6 |
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| CAS: | 75330-75-5 |
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| MI: | 14: 5586 |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>35mg/ml); insoluble in water. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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