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C. difficile toxin B

BML-G150-0050 50 µg 1,042.00 USD
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  • High potency retained following inactivation
  • Minimal lot-to-lot variation
  • Lyophilized for ease of handling and long term stability
Extremely potent cytotoxin.

Product Details

Alternative Name:Clostridium difficile toxin B
Source:From Clostridium difficile, strain VPI10463.
UniProt ID:P18177
Formulation:Lyophilized. Contains 0.05M HEPES, 0.15M sodium chloride and 5% sucrose.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified protein.
Appearance:Clear residue.
Biological Activity:2 pg/ml by verocytotoxicity assay (lowest point at which cell rounding is visible)
Antibody capture, Cytotoxicity studies, LINE assay
Reconstitution:Reconstitute in 250µl sterile distilled water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:After reconstitution, prepare aliquots and store at -80°C.
Regulatory Status:RUO - Research Use Only

Product Literature References

Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract;
Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon: A.P. Franch, et al.; Elife 11, e73675 (2022), Abstract;
Enteric glial cells are susceptible to Clostridium difficile toxin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 74, 1527 (2017), Abstract;

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