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Diphtheria toxin (Corynebacterium diphtheriae)

BML-G135-0001 1 mg 1,026.00 USD
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Product Details

Source:From Corynebacterium diphtheriae.
Reconstitution:Reconstitute with 0.5mL of sterile distilled water
Shipping:Ambient Temperature
Long Term Storage:+4°C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C
Scientific Background:Elongation factor 2 (EF-2) catalyzes the GTP hydrolysis-dependent translocation reaction that is responsible for the movement of the ribosome along mRNA during protein synthesis. Diphtheria toxin catalyzed ADP-ribosylation of EF-2 inhibits the translocation reaction which halts protein synthesis and ultimately results in cell death. Diphtheria toxin is cell permeable and can translocate across endosomal membranes in response to low pH3.
Regulatory Status:RUO - Research Use Only

Product Literature References

Development of a bead-based multiplex immunoassay for simultaneous quantitative detection of IgG serum antibodies against seven vaccine-preventable diseases: E.N. Bykonia, et al.; J. Immunol. Methods 512, 113408 (2023), Abstract;
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota: X. Liu, et al.; Nat. Immunol. 23, 1564 (2022), Abstract;
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity: A.T. Krishnamurty, et al.; Nature 611, 148 (2022), Abstract;
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues: V. Kapoor, et al.; Nat. Immunol. 22, 571 (2021), Abstract;
Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo: O. Sonzogni, et al.; PLOS Biol. 16, e2004049 (2018), Abstract;

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