Product Details
| Source: | From Corynebacterium diphtheriae. |
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| EC: | 2.4.2.36 |
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| Formulation: | Lyophilized. |
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| Reconstitution: | Reconstitute with 0.5mL of sterile distilled water |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C |
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| Scientific Background: | Elongation factor 2 (EF-2) catalyzes the GTP hydrolysis-dependent translocation reaction that is responsible for the movement of the ribosome along mRNA during protein synthesis. Diphtheria toxin catalyzed ADP-ribosylation of EF-2 inhibits the translocation reaction which halts protein synthesis and ultimately results in cell death. Diphtheria toxin is cell permeable and can translocate across endosomal membranes in response to low pH3. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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512, 113408 (2023),
Abstract;
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23, 1564 (2022),
Abstract;
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity: A.T. Krishnamurty, et al.; Nature
611, 148 (2022),
Abstract;
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues: V. Kapoor, et al.; Nat. Immunol.
22, 571 (2021),
Abstract;
Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo: O. Sonzogni, et al.; PLOS Biol.
16, e2004049 (2018),
Abstract;
