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Cholera toxin (Vibrio cholerae), (azide free)

G protein activator
BML-G117-0001 1 mg 431.00 USD
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Product Details

Source:From Vibrio cholerae.
UniProt ID:P01555 (A subunit), P01556 (B subunit)
Formulation:Lyophilized from 0.05M Tris, pH 7.5, containing 200 mM NaCl, and 1 mM Na2 EDTA.
Reconstitution:Reconstitute with 0.5ml sterile water to a 2mg/mL solution.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Handle gently and do not vortex. Store at +4°C prior to and following reconstitution. Do not freeze.
Scientific Background:Cholera toxin consists of a single A subunit surrounded by five B subunits. The B subunits are responsible for the attachment of the native toxin to ganglioside GM1 on mammalian cell surfaces, and facilitate translocation of the A subunit. The A subunit catalyzes the ADP-ribosylation of an arginine residue on the a subunit of G proteins, reducing intrinsic GTPase activity and activating the a subunit. ADP-ribosylation of other proteins such as human red cell Ca-ATPase has also been reported. Cholera toxin must interact with ADP-ribosylation factor (ARF) for maximal activity.
Regulatory Status:RUO - Research Use Only

Product Literature References

A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells: A.M. Porman, et al.; PLoS Biol. 20, e3001885 (2022), Abstract;
Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells: P. Hoffmann, et al.; PLoS One 16, e0257824 (2021), Abstract;
Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks: S.F. Darling-Reed, et al.; Biomolecules 11, 1313 (2021), Abstract;

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