Iron chelator. Inhibits ferric ion catalyzed formation of hydroxyl radicals. A very potent ligand for the chelation of ferric iron in vivo (active in rat models but inactive in primate models). Inhibits neutrophil apoptosis. An important tool for probing the involvement of hydroxyl radicals in cellular processes.
Product Details
| Formula: | C20H24N2O6 . HCl . H2O |
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| MW: | 442.9 |
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| CAS: | 35369-53-0 |
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| Purity: | ≥95% (NMR) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml), in ethanol at 40°C (25mg/ml), in water (4mg/ml) at 50°C with vigorous agitation (approximately 15 minutes). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at 20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network: B. Faller, et al.; J. Med. Chem.
43, 1467 (2000),
Abstract;
Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis: E. Rollet-Labelle, et al.; Free Radic. Biol. Med.
24, 563 (1998),
Abstract;
Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells: A. Gozin, et al.; Free Radic. Biol. Med.
25, 1021 (1998),
Abstract;
