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U-83836E

Antioxidant
 
BML-FR101-0100 100 mg 126.00 USD
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The lazaroid U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells and reduces secondary brain injury in a rabbit model of cryogenic trauma.

Product Specification

Alternative Name:(-)-2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol . 2HCl
 
Formula:C30H44N6O2 . 2HCl
 
MW:593.6
 
CAS:122003-11-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (30 mg/ml) or ethanol (>50 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Propofol Ameliorates Calpain-induced Collapsin Response Mediator Protein-2 Proteolysis in Traumatic Brain Injury in Rats: Y. Yu, et al.; Chin. Med. J. (Engl). 128, 919 (2015), Application(s): Injection in rat, Abstract; Full Text
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995), Abstract; Full Text
Lazaroids and deferoxamine attenuate the intracellular effects of oxyhaemoglobin in vascular smooth muscle: B. Vollrath, et al.; Cardiovasc. Res. 30, 619 (1995), Abstract;
U83836E reduces secondary brain injury in a rabbit model of cryogenic trauma: J. T. Wilson, et al.; J. Trauma 39, 473 (1995), Abstract;

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