Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


Blocks lipid peroxidation
BML-FR100-0100 100 mg 125.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-270-265

Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant. Inhibits lipid peroxidation in a variety of experimental systems including cultured brain microvessel endothlial cells, Cu2+ treated monocyclic THP1 cells and LLC-PK1 cell layers where it blocks F2 isoprostane production. Prevented organ damage in intestinal cold storage, preservation and reperfusion injury.

Product Specification

Alternative Name:21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
Formula:C37H50N6O2 . C4H4O4
Purity:≥95% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml). Insoluble in water.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

UPLC-MS/MS Assay of 21-Aminosteroid (Lazaroid U74389G) for Application in Pharmacokinetic Study: P. Gadgil, et al.; J. Pharm. Biomed. Anal. 122, 90 (2016), Application(s): UPLC-MS/MS assay of lazaroid in rat plasma, Abstract;
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 125, 421 (1999), Abstract;
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res. 816, 471 (1999), Abstract; Full Text
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999), Abstract;
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998), Abstract;
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998), Abstract;
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998), Abstract;
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998), Abstract;
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997), Abstract;
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996), Abstract;
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996), Abstract;
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995), Abstract;
Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants: D.J. Crutchley & B.G. Que; Circulation 92, 238 (1995), Abstract;
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995), Abstract;
Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution: S.M. Katz, et al.; Transplantation 59, 694 (1995), Abstract;

Related Literature

Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

All new literature pieces

Recommend this page

Keep in touch

©2020 Enzo Life Sciences, Inc.,