Has been shown to inhibit dietary-restriction-induced lifespan extension in wild-type and TOR pathway mutant nematodes. This data indicates that reduced N-acylethanolamide signaling mediates some of the effect of dietary-restriction-induced lifespan extension and that EPEA, specifically, acts as a metabolic signal that couples nutrient availability with growth and lifespan. EPEA has also been shown to have anti-proliferative effects and anti-inflammatory properties. Compound is subject to oxidation. Protect from air.
Product Details
| Alternative Name: | EPEA |
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| Formula: | C22H35NO2 |
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| MW: | 345.5 |
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| Source: | Synthetic. |
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| CAS: | 109001-03-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale amber oil. |
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| Solubility: | Soluble in DMSO (20mg/ml) or in 100% ethanol (25mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Protect from air. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
N-acylethanolamine signaling mediates the effect of diet on lifespan in Caenorhabditis elegans: M. Lucanic, et al.; Nature
473, 226 (2011),
Abstract;
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3-ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines : I. Brown, et al. ; Carcinogenesis
31, 1584 (2010),
Abstract;
Docosahexaenoic and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acylethanolamines with anti-inflammatory properties: M. Balvers, et al.; Biochim. Biophys. Acta
1801, 1107 (2010),
Abstract;
