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Oleic acid

PKC activator
BML-FA045-0010 10 g 125.00 USD
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Replaces Prod. #: ALX-300-138

Major mono-unsaturated fatty acid constituent of olive oil occurring as the glyceride. Activates protein kinase C (PKC) in hepatocytes. Inhibitor of glucose production and food intake. Upregulates the expression of uncoupling protein-3 (UCP-3) in L6 myotubes. Promotes differentiation of cultured neuronal cells mediated via PPARβ and it induces a myofibroblast-like phenotype in mesangial cells.

Product Details

Alternative Name:cis-9-Octadecenoic acid 18:1
MI:14: 6828
Purity:≥99% (GC)
Appearance:Colorless oil/low-melting solid.
Solubility:Soluble in 100% ethanol (>25mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C under inert gas.
Handling:Protect from light and oxygen. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro: S.F. Petry, et al.; Antioxidants 11, 788 (2022), Abstract;
Oleate induces a myofibroblast-like phenotype in mesangial cells: R. Mishra & M.S. Simonson; Arterioscler. Thromb. Vasc. Biol. 28, 541 (2008), Abstract;
Active components and clinical applications of olive oil: E. Waterman & B. Lockwood; Altern. Med. Rev. 12, 331 (2007), Abstract;
PPARbeta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y: S. Di Loreto, et al.; J. Cell Physiol. 211, 837 (2007), Abstract;
Effects of rosiglitazone and oleic acid on UCP-3 expression in L6 myotubes: A. Costello, et al.; Diabetes Obes. Metab. 5, 136 (2003), Abstract;
Central administration of oleic acid inhibits glucose production and food intake: S. Obici, et al.; Diabetes 51, 271 (2002), Abstract; Full Text
Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro: L.L. Williams, et al.; Proc. Soc. Exp. Biol. Med. 202, 239 (1993), Abstract;
Free fatty acid-induced alterations in the steroid-binding properties of rat androgen-binding protein: F. Felden, et al.; BBRC 190, 602 (1993), Abstract;
Spinal cord of the rat contains more lipoprotein lipase than other brain regions: D.H. Bessesen, et al.; J. Lipid Res. 34, 229 (1993), Abstract;
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes: M.J. Diaz-Guerra; J. Biol. Chem. 266, 23568 (1991), Abstract; Full Text