Replaces Prod. #: ALX-340-036
Endogenous ligand for the CB1 receptor (CB1: Ki=58.3nM); CB2: Ki>3µM) present in high levels in the CNS.
Product Details
| Alternative Name: | 2-AG |
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| Formula: | C23H38O4 |
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| MW: | 378.6 |
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| CAS: | 53847-30-6 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by IR. |
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| Appearance: | Oil. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -70°C. Stock solutions are stable for up to 3 months when stored at -70°C under an atmosphere of nitrogen or argon. |
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| Handling: | Protect from light and oxygen. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity: S. Petrosino, et al.; J. Neuroinflammation
16, 274 (2019),
Abstract;
Full Text
2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells: M. Gokoh, et al.; Biochem. J.
386, 583 (2005),
Abstract;
Full Text
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells: K. Nithipatikom, et al.; BBRC
332, 1028 (2005),
Abstract;
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci.
8, 1139 (2005),
Abstract;
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells: S. Kishimoto, et al.; J. Biochem.
135, 517 (2004),
Abstract;
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res.
64, 8826 (2004),
Abstract;
Full Text
New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation: T. Sugiura, et al.; J. Pharmacol. Sci.
96, 367 (2004),
Abstract;
Full Text
The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein: G.J. Maestroni; FASEB J.
18, 1914 (2004),
Abstract;
Full Text
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain: T. Bisogno, et al.; J. Cell Biol.
163, 463 (2003),
Abstract;
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors: T. Bisogno, et al.; Eur. J. Biochem.
268, 1982 (2001),
Abstract;
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors: S.K. Goparaju, et al.; Biochem. Pharmacol.
57, 417 (1999),
Abstract;
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds: T. Sugiura, et al.; J. Biol. Chem.
274, 2794 (1999),
Abstract;
Full Text
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments: V. Di Marzo, et al.; Lipids
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Abstract;
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanis: S. Kondo, et al.; FEBS Lett.
429, 152 (1998),
Abstract;
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity: S. Ben-Shabat, et al.; J. Pharmacol.
353, 23 (1998),
Abstract;
A second endogenous cannabinoid that modulates long-term potentiation: N. Stella, et al.; Nature
388, 773 (1997),
Abstract;
