Replaces Prod. #: ALX-340-010
Inhibits arachidonic acid uptake. Inhibits cyclooxygenase (ID50=8 µM) and all lipoxygenases (ID50=10, 0.3, and 0.2 µM for 5-, 12- and 15-LO respectively) in whole cells. Inhibits PLA2 and cytochrome P-450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. PPAR agonist.
Product Details
| Alternative Name: | ETYA |
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| Formula: | C20H24O2 |
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| MW: | 296.5 |
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| CAS: | 1191-85-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, DMSO, acetone or acetonitrile. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Make solutions fresh daily. |
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| Handling: | Protect from light and oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One
6, e25395 (2011),
Abstract;
Full Text
Activation of TRPA1 by farnesyl thiosalicylic acid: M. Maher, et al.; Mol. Pharmacol.
73, 1225 (2008),
Abstract;
Effects of 5,8,11,14-eicosatetraynoic acid on thapsigargin-induced calcium entry, and intracellular pH in thyroid FRTL-5 cells: E. Ekokoski & K. Tornquist; Biochim. Biophys. Acta
1223, 274 (1994),
Abstract;
Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14- eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4: F. Ondrey, et al.; Cancer Res.
49, 1138 (1989),
Abstract;
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification: A.S. Taylor, et al.; Prostaglandins
29, 449 (1985),
Abstract;
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med.
13, 53 (1984),
Abstract;
The mechanism of inactivation of lipoxygenases by acetylenic fatty acids: H. Kühn, et al.; Eur. J. Biochem.
139, 577 (1984),
Abstract;
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC
114, 743 (1983),
Abstract;
Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites: E.Y. Chi, et al.; Lab. Invest.
47, 579 (1982),
Abstract;
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes: G.M. Bokoch & P.W. Reed; J. Biol. Chem.
256, 4156 (1981),
Abstract;
Full Text
An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells: P.M. Conn, et al.; Prostaglandins
19, 873 (1980),
Abstract;
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism: L.D. Tobias & J.G. Hamilton; Lipids
14, 181 (1979),
Abstract;
Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase: D.T. Downing, et al.; Biochim. Biophys. Acta
280, 343 (1972),
Abstract;
