Replaces Prod. #: ALX-340-009
Inhibits lipoxygenases (ID50=3, 20 and 20µM for 5-, 12- and 15-LO respectively) selectively over cyclooxygenase (ID50=50µM) in whole cells. Also inhibits hepatic glutathione S-transferase and leukotriene C4 biosynthesis.
Product Details
| Alternative Name: | ETI |
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| Formula: | C20H28O2 |
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| MW: | 300.4 |
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| CAS: | 13488-22-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in ethanol (25mg/ml), DMSO (25mg/ml) or dimethyl formamide. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light and oxygen. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death: R.G. Fred, et al.; Mol. Cell. Endocrinol.
414, 53 (2015),
Application(s): Cell culture ,
Abstract;
Inhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids: K. Datta & A.P. Kulkarni; Toxicol. Lett.
73, 157 (1994),
Abstract;
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostaglandins Leukot. Med.
13, 53 (1984),
Abstract;
Inhibition of leukotriene C and leukotriene D biosynthesis: L. Orning & S. Hammarstrom; J. Biol. Chem.
255, 8023 (1980),
Abstract;
Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid: S. Hammarstrom; Biochim. Biophys. Acta
487, 517 (1977),
Abstract;
