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Tesmilifene

Antagonist of intracellular histamine



BML-EI401-0010	10 mg	78.00 USD

BML-EI401-0050	50 mg	308.00 USD
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Tesmilifene is a novel agent that augments cytotoxicity of various chemotherapeutic agents both in vitro and in vivo. It binds selectively to the high-affinity microsomal antiestrogen binding site (Ki=50nm) but has no affinity for estrogen receptors. Inhibits concanavalin-A-induced histamine release in mast cells and acts as a novel antagonist of intracellular histamine.

Product Specification

Alternative Name:	DPPE, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine . HCl

Formula:	C₁₉H₂₅NO . HCl

MW:	283.4 . 36.5

CAS:	92981-78-7

MI:	14: 9178

Purity:	≥99% (TLC)

Appearance:	Off-white solid.

MeltingPoint:	150-152°C

Solubility:	Soluble in water (4mg/ml) or DMSO (3mg/ml).

Shipping:	Ambient

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene.: P. J. Ferguson, et al.; Cancer Lett. 274, 279 (2009), Abstract;

Phase III study of N,N-diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group St: L. Reyno, et al.; J. Clin. Oncol. 22, 269 (2004), Abstract;

Synergy between tamoxifen and cisplatin in human melanoma cells is dependent on the presence of antiestrogen-binding sites.: J.A. Jones, et al.; Cancer Res. 57, 2657 (1997), Abstract;

Influence of DPPE on histamine release from isolated rat mast cells.: N. Grosman; Agents Actions 41, 1 (1994), Abstract;

Histamine is an intracellular messenger mediating platelet aggregation.: S.P: Saxena, et al.; Science 243, 1596 (1989), Abstract;