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VAS-2870

NADPH oxidase inhibitor
 
BML-EI395-0010 10 mg 117.00 USD
 
BML-EI395-0050 50 mg 469.00 USD
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Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).

Product Specification

Alternative Name:3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine
 
Formula:C18H12N6OS
 
MW:360.4
 
CAS:722456-31-7
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC: W.J. Lu, et al.; Sci. Rep. 11, 18852 (2019), Abstract; Full Text
Detrimental role of pericyte Nox4 in the acute phase of brain ischemia: A. Nishimura, et al.; J. Cereb. Blood Flow Metab. 36, 1143 (2016), Application(s): Cell Culture, Abstract; Full Text
Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development: C. Gauron, et al.; Dev. Biol. 414, 133 (2016), Application(s): Zebrafish embryos were incubated in VAS-2870 (Nox-i) (100 nM), Abstract;
Activation of PPAR╬┤ prevents endothelial dysfunction induced by overexpression of amyloid-╬▓ precursor protein: L.V. d'Uscio, et al.; Cardiovasc. Res. 96, 504 (2012), Application(s): Western Blot of mouse aorta lysates, Abstract; Full Text
H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling: J.F. Wooley, et al.; PLoS One 7, e34050 (2012), Abstract; Full Text
Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species: S. Lange, et al.; Cardiovasc. Res. 81, 159 (2009), Abstract;
Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells: C. Stielow, et al.; BBRC 344, 200 (2006), Abstract;
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation: H. ten Freyhaus, et al.; Cardiovasc. Res. 71, 331 (2006), Abstract;

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