Cell permeable inhibitor of RhoA- and RhoC-mediated signaling. Inhibits LPA-induced DNA synthesis in PC-3 prostate cancer cell lines (<1µM) and inhibits the growth of RhoC-overexpressing melanoma cell lines (A375M2 and SK-Mel-147) at nanomolar concentrations.
Product Details
| Alternative Name: | N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide |
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| Formula: | C18H13ClF6N2O3 |
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| MW: | 454.8 |
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| CAS: | 285986-88-1 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) or 100% ethanol (9mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling: C.R. Evelyn, et al.; Mol. Cancer Ther.
6, 2249 (2007),
Abstract;
