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Epoxide hydrolase inhibitor
 
BML-EI392-0010 10 mg 64.00 USD
 
BML-EI392-0050 50 mg 316.00 USD
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Novel inhibitor of soluble epoxide hydrolase (IC50=18nM and 69nM for the mouse and human enzymes respectively). Produces a hypotensive effect in angiotensin-infused rats and prevents and reverses cardiac hypertrophy in mouse models of cardiac hypertrophy.

Product Details

Alternative Name:12-(3-Adamantan-1-yl-ureido)-dodecanoic acid
 
Formula:C21H36N2O3
 
MW:392.5753   
 
CAS:479413-70-2
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10mg/ml) or 100% ethanol (4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors: D. Xu, et al.; PNAS U.S.A. 103, 18733 (2006), Abstract;
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension: J.D. Imig, et al.; Hypertension 46, 975 (2005), Abstract;
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases: C. Morisseau, et al.; Biochem. Pharmacol. 63, 1599 (2002), Abstract;

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