A selective PI 3-Kγ isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70μM for α, β, γ and δ isoforms respectively). Blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models.
Product Details
| Alternative Name: | NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione |
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| Formula: | C11H7NO4S |
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| MW: | 249.2 |
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| CAS: | 6318-41-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/mL). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: C. Ferrandi, et al.; J. Pharmacol. Exp. Ther.
322, 923 (2007),
Abstract;
