DAPH abolishes or greatly reduces previously existing fully formed β-amyloid (1-42) fibrils and eliminates β-amyloid (1-42) peptide neurotoxicity. Also inhibits EGFR kinase. IC50 for inhibition of β-sheet content of aggregated β-amyloid (1-42) is 4.5µM.
Product Details
| Alternative Name: | 4,5-Dianilinophthalimide, CGP-52411 |
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| Formula: | C20H15N3O2 |
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| MW: | 329.4 |
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| CAS: | 145915-58-8 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs: H. Wang, et al.; Proc. Natl. Acad. Sci. USA
105, 7159 (2008),
Abstract;
Full Text
Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule: B. J. Blanchard, et al.; Proc. Natl. Acad. Sci. USA
101, 14326 (2004),
Abstract;
Full Text
Transforming growth factor-alpha acting at the epidermal growth factor receptor reduces infarct volume after permanent middle cerebral artery occlusion in rats: C. Justicia & A. M. Planas; J. Cereb. Blood Flow. Metab.
19, 128 (1999),
Abstract;
