A selective inhibitor of p38α (IC50 = 3.2nM) and p38β (IC50 = 3.2nM), but not p38γ (IC50 > 50μM), ERK2, JNK1 or MAPKAP2. Lowers blood glucose and improves glucose homeostasis in nonobese diabetic mice. Enhances axonal regeneration in animals with nerve transection.
Product Details
| Alternative Name: | 1H-Indole-5-carboxamide |
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| Formula: | C9H8N2O |
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| MW: | 160.2 |
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| CAS: | 1670-87-7 |
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| Purity: | ≥96.5% (HPLC) |
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| Identity: | Determined by IR. |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in water (1.5mg/ml); DMSO (15mg/ml) or Ethanol (15mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes: S. Medicheria, et al.; J. Pharmacol. Exp. Ther.
318, 99 (2006),
Abstract;
Full Text
Inhibition of p38 MAP kinase activity enhances axonal regeneration: R. R. Myers, et al.; Exp. Neurol.
184, 606 (2003),
Abstract;
