Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.
Product Details
| Alternative Name: | 6-Nitro[b]thiophene-1,1-dioxide |
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| Formula: | C8H5NO4S |
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| MW: | 211.2 |
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| CAS: | 19983-44-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml), 100% ethanol (10 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on KATP channel activation: B. Schnabel, et al.; Mol. Vis.
26, 797 (2020),
Abstract;
Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling: F. Doktor, et al.; Purinergic Signal.
14, 471 (2018),
Abstract;
STAT3 Knockdown Induces Tumor Formation by MDA-MB-231 Cells: K. Banerjee, et al.; Clin. Oncol. Res. (2018),
Abstract;
Full Text
Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling: M. Hollborn, et al.; Mol. Vis.
23, 116 (2017),
Abstract;
Full Text
Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA: A. Brosig, et al.; Mol. Vis.
21, 1000 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5: M. Hollborn, et al.; Mol. Vis.
21, 360 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Effects of interleukin-15 on neuronal differentiation of neural stem cells: Y.S. Huang, et al.; Brain Res.
1304, 38 (2009),
Abstract;
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria: L. Samavati, et al.; Mol. Immunol.
46, 1867 (2009),
Abstract;
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization: J. Schust, et al.; Chem. Biol.
13, 1235 (2006),
Abstract;
