Highly potent inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).
Product Details
| Alternative Name: | 2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide |
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| Formula: | C20H16F3N3O |
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| MW: | 371.4 |
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| CAS: | 269390-77-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis: P. W. Manley, et al.; Biochim. Biophys. Acta
1697, 17 (2004),
Abstract;
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors: P. W. Manley, et al.; J. Med. Chem.
45, 5687 (2002),
Abstract;
