Benzylpiperidine inhibitor of p38α (IC50 = 32 nM). Selective over p38γ (IC50 10 µM).
Product Details
| Alternative Name: | 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine |
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| Formula: | C21H25NO2S |
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| MW: | 355.5 |
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| CAS: | 349087-34-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast: Y. Friedmann, et al.; Mol. Pharmacol.
70, 1395 (2006),
Abstract;
