A selective inhibitor of MEK1 and MEK2 (IC50= 0.18 and 0.22 µM respectively). Displays neuroprotective effects against ischemic brain injury.
Product Details
| Alternative Name: | [Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile |
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| Formula: | C16H12F3N3S |
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| MW: | 335.4 |
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| CAS: | 305350-87-2 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO to 100 mM or in ethanol to 100 mM. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of extracellular signal-regulated kinase pathway suppresses tracheal stenosis in a novel mouse model: A. Kimura, et al.; PLoS One
169, e0256127 (2021),
Abstract;
Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells: A. Sato, et al.; Stem Cell Res.
12, 119 (2014),
Application(s): WB of human glioma-initiating cells,
Abstract;
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis: X. Wang, et al.; J. Pharmacol. Exp. Ther.
304, 172 (2003),
Abstract;
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Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy: P. A. Scherle, et al.; J. Biol. Chem.
275, 37086 (2000),
Abstract;
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