Potent and selective inhibitor of NGFR kinase (TrkA, IC50=2 nM). Blocks TrkA-mediated γH2AX production and apoptosis in TrkA-overexpressing cells.
Product Details
| Formula: | C17H13N3O |
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| MW: | 275.3 |
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| CAS: | 504433-23-3 |
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| Purity: | ≥98% (TLC); mixture of E and Z isomers |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells: E.J. Jung, et al.; Exp. Mol. Med.
40, 276 (2008),
Abstract;
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