HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A. It inhibits cerebrovascular constriction induced by Ca2+ or arachidonate and inhibits angiogenesis and endothelial cell sprouting in various models.
Product Details
| Alternative Name: | N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidine |
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| Formula: | C12H18N2O |
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| MW: | 206.3 |
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| CAS: | 339068-25-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Light pink solid. |
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| Solubility: | Soluble in DMSO (6 mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia: S. M. Poloyac, et al.; J. Cereb. Blood Flow Metab.
26, 1551 (2006),
Abstract;
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions: S. J. Mulligan & B. A. MacVicar; Nature
431, 195 (2004),
Abstract;
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels: Jiang, et al.; Circ. Res.
94, 167 (2004),
Abstract;
Full Text
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis: S. L. Amaral, et al.; Am. J. Physiol. Heart Circ. Physiol.
284, H1528 (2003),
Abstract;
Full Text
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme: N. Miyata, et al.; Br. J. Pharmacol.
133, 325 (2001),
Abstract;
