Replaces Prod. #: ALX-550-410
Originally described as a potent and selective inhibitor of MAG lipase which selectively raises levels of 2-arachidonoylglycerol (2AG). Subsequent studies have shown that that URB-754 does not inhibit recombinant MAG Lipase and that the original activity was due to a contaminant, bis(methylthio)mercurane, in another commercial source.
Product Details
| Formula: | C16H14N2O2 |
| |
| MW: | 266.3 |
| |
| CAS: | 86672-58-4 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | Off-white solid. |
| |
| MeltingPoint: | 238-240°C |
| |
| Solubility: | Soluble in DMSO (15mg/ml) |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Erratum: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci.
10, 134 (2007),
Full Text
Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro: S. Vandervoorde, et al.; Br. J. Pharmacol.
150, 186 (2007),
Abstract;
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain: S.M. Saario, et al.; Chem. Biol.
13, 811 (2006),
Abstract;
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci.
8, 1139 (2005),
Abstract;
