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URB-602

Monoacylglycerol lipase inhibitor
 
BML-EI348-0050 50 mg Inquire for pricing
 
BML-EI348-0010 10 mg Inquire for pricing
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Replaces Prod. #: ALX-550-519

Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.

Product Specification

Alternative Name:Biphenyl-3-yl carbamic acid cyclohexyl ester
 
Formula:C19H21NO2
 
MW:295.4
 
CAS:565460-15-3
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
MeltingPoint:122-123ºC
 
Solubility:Soluble in DMSO (30 mg/ml) or ethanol (5 mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

An endocannabinoid mechanism for stress-induced analgesia: A.G. Hohmann et al.; Nature 435, 1108 (2005), Abstract;

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