Replaces Prod. #: ALX-270-371
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
Product Details
Alternative Name: | DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester |
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Formula: | C6H9NO5 |
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MW: | 175.1 |
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CAS: | 89464-63-1 |
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Purity: | ≥98% (HPLC) |
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Appearance: | Off-white solid. |
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Solubility: | Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml) or dimethyl formamide; soluble also in PBS, pH7.2 (10mg/ml). |
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Shipping: | Dry Ice |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Inhibition Assay,
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