Replaces Prod. #: ALX-385-008
Apigenin is an antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. Is a MAP-Kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. Induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels. Apigenin is a selective inhibitor of CK2. In WEHI 231 cells inhibition of CK2 by apigenin decreased the rate of IκBα turnover and nuclear levels of NF-κB (20 µM). It blocks proliferation of Wnt-1 transfected cells and abrogates phosphorylation of β-catenin. In a rat model of glomerulonephritis, inhibition of CK2 by apigenin ameliorates renal dysfunction.
Product Details
| Formula: | C15H10O5 |
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| MW: | 270.2 |
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| CAS: | 520-36-5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | light yellow to slightly brown powder |
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| Solubility: | Soluble in diluted potassium hydroxyde or DMSO, slightly soluble in 100% ethanol (hot). Insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Enzymatic synthesis of α-flavone glucoside via regioselective transglucosylation by amylosucrase from Deinococcus geothermalis: S.W. Jang, et al.; PLoS One
13, e0207466 (2018),
Abstract;
Gastric relaxation induced by apigenin and quercetin: analysis of the mechanism of action: A. Rotondo et al.; Life. Sci.
85, 85 (2009),
Abstract;
Apigenin and cancer chemoprevention: progress, potential and promise (review): D. Patel et al.; Int. J. Oncol.
30, 233 (2007),
Abstract;
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas et al.; J. Immunol.
179, 7121 (2007),
Abstract;
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang et al.; Carcinogenesis
28, 858 (2007),
Abstract;
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle
6, 1102 (2007),
Abstract;
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10699950: R. Torkin et al.; Mol. Cancer. Ther.
4, 1 (2005),
Abstract;
Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis: M. Yamada et al.; PNAS
102, 7736 (2005),
Abstract;
Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha: J. Shen et al.; J. Immunol.
167, 4919 (2001),
Abstract;
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon et al.; Int. J. Cancer.
85, 691 (2000),
Abstract;
Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells: D.H. Song et al.; J. Biol. Chem.
275, 23790 (2000),
Abstract;
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C. Rice-Evans et al.; Free Radic. Biol. Med.
20, 933 (1996),
Abstract;
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M. L. Kuo et al.; Biochem. Biophys. Res. Commun.
212, 767 (1995),
Abstract;
Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet et al.; Carcinogenesis
15, 2325 (1994),
Abstract;
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato et al.; Biochem. Biophys. Res. Commun.
204, 578 (1994),
Abstract;
