Replaces Prod. #: ALX-270-487
Potent inhibitor of Cdk5/p25 (IC50=64 nM). Also inhibits Cdk2/cyclin E (IC50=98nM).
Product Details
| Alternative Name: | N-(5-Isopropylthiazol-2-yl)phenylacetamide |
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| Formula: | C14H16N2OS |
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| MW: | 260.4 |
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| CAS: | 267654-00-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 150-152°C |
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| Solubility: | Soluble in DMSO (30mg/ml), dimethyl formamide (30mg/ml) or 100% ethanol (0.25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease: C.J. Helal, et al.; Bioorg. Med. Chem. Lett.
14, 5521 (2004),
Abstract;
