A selective COX-2 inhibitor (IC50=0.8 µM) that covalently modifies the enzyme by acetylation of Ser530. APHS is an inhibitor of HIV-1 replication.
Product Details
| Alternative Name: | 2-Acetoxyphenylhept-2-ynylsulfide |
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| Formula: | C15H18O2S |
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| MW: | 262.4 |
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| CAS: | 209125-28-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Oil. |
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| Solubility: | Soluble in DMSO (5mg/ml) or 100% ethanol (8mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication: C. F. Pereire, et al.; Antiviral Res.
58, 253 (2003),
Abstract;
Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide: P. Hochgesang, et al.; Arch. Biochem. Biophys.
409, 127 (2003),
Abstract;
Aspirin-like molecules that covalently inactivate cyclooxygenase-2: A. S. Kalgurkar, et al.; Science
280, 1268 (1998),
Abstract;
