Replaces Prod. #: ALX-270-018
Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.
Product Details
| Alternative Name: | α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile |
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| Formula: | C10H5N3O4 |
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| MW: | 231.2 |
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| CAS: | 116313-73-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale orange solid. |
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| Solubility: | Soluble in DMSO (35mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tyrphostins are inhibitors of guanylyl and adenylyl cyclases.: M. Jaleel et al.; Biochemistry
43, 8247 (2004),
Abstract;
Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells.: T. Zakar et al.; Can. J. Physiol. Pharmacol.
77, 138 (1999),
Abstract;
Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors.: A. Novogrodsky et al.; Science
264, 1319 (1994),
Abstract;
