Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt1. In whole cells triciribine is phosphorylated by adenosine kinase which may be necessary for its activity.
Product Details
| Formula: | C13H16N6O4 |
| |
| MW: | 320.3 |
| |
| CAS: | 35943-35-2 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | Pale yellow solid |
| |
| Solubility: | Soluble in DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Visfatin Promotes Monocyte Adhesion by Upregulating ICAM-1 and VCAM-1 Expression in Endothelial Cells via Activation of p38-PI3K-Akt Signaling and Subsequent ROS Production and IKK/NF-κB Activation: Y.T. Lin, et al.; Cell. Physiol. Biochem.
52, 1398 (2019),
Abstract;
Full Text
cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells: M.T. Majorini, et al.; Cell Death Differ.
25, 2147 (2018),
Abstract;
Full Text
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt: L. Yang et al.; Cancer Res.
64, 4394 (2004),
Abstract;
Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation: R. A. Porcari et al.; J. Med. Chem.
43, 2438 (2000),
Abstract;
Inhibition of CCRF-CEM human leukemic lymphoblasts by triciribine (tricyclic nucleoside, TCN, NSC-154020). Accumulation of drug in cells and comparison of effects on viability, protein synthesis and purine synthesis: E. C. Moore et al.; Biochem. Pharmacol.
38, 4037 (1989),
Abstract;
