Selective COX-2 inhibitor (IC50=60nM).
Product Details
| Alternative Name: | N-(2-Phenylethyl)Indomethacin amide |
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| Formula: | C27H25ClN2O3 |
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| MW: | 461.0 |
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| CAS: | 261766-32-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow solid. |
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| MeltingPoint: | 152-154°C |
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| Solubility: | Soluble in DMSO (25 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20ºC for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors: A.S. Kalgutkar, et al.; PNAS
97, 925 (2000),
Abstract;
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors: A.S. Kalgutkar, et al.; J. Med. Chem.
43, 2860 (2000),
Abstract;
