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AICAR

AMPK activator



BML-EI330-0050	50 mg	106.00 USD

BML-EI330-0250	250 mg	431.00 USD
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An adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP), which stimulates AMPK activity. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. Induces the phosphorylation of TORC2 and inhibits its entry into the nucleus. Mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase. Inhibits PPARα coactivation and adipocyte differentiation. Substrate for the AICAR transformylase activity of ATIC. Inhibits the growth of prostate cancer cells by inhibiting fatty ascid synthesis. Supresses LPS-induced TNF production via the inhibition of Akt activation. Induces apoptosis in Jurkat cells via a non-AMPK pathway.

Product Details

Alternative Name:	5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine

Formula:	C₉H₁₄N₄O₅

MW:	258.2

CAS:	2627-69-2

Purity:	≥98% (TLC)

Appearance:	Off-white solid.

Solubility:	Soluble in water (9mg/ml).

Shipping:	Ambient

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Inhibitory role of AMP‑activated protein kinase in necroptosis of HCT116 colon cancer cells with p53 null mutation under nutrient starvation: D.T. Le, et al.; Int. J. Oncol. 54, 702 (2019), Abstract;

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms: M. Panse, et al.; PLoS One 13, e0198016 (2018), Abstract; Full Text

Resveratrol Up-regulates AMPA Receptor Expression via AMP-activated protein kinase - mediated Protein Translation: G. Wang, et al.; Neuropharmacology 95, 144 (2015), Application(s): Cell Culture, Western Blotting, Abstract;

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism: S. H. Koo et al.; Nature 437, 1109 (2005), Abstract;

5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages: B. S. Jhun et al.; Biochem. Biophys. Res. Commun. 318, 372 (2004), Abstract;

AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms: X. Xiang et al.; Biochem. Biophys. Res. Commun. 321, 161 (2004), Abstract;

Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase: M. Bronner et al.; Biochem. J. 384, 295 (2004), Abstract;

5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved: J. M. Lopez et al.; Biochem. J. 370, 1027 (2003), Abstract;

The effects of AICAR on adipocyte differentiation of 3T3-L1 cells: S. A. Habinowski et al.; Biochem. Biophys. Res. Commun. 286, 852 (2001), Abstract;

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase: P. A, Lochhead et al.; Diabetes 49, 896 (2000), Abstract;

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?: J. M. Corton et al.; Eur. J. Biochem. 229, 558 (1995), Abstract;