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Acetyl-CoA inhibitor
BML-EI321-0010 10 mg 95.00 USD
BML-EI321-0050 50 mg 405.00 USD
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Replaces Prod. #: ALX-270-402

Hypolipidemic agent. Potent, reversible and competitive inhibitor of acetyl-coenzyme A carboxylase (Ac-CoA carboxylase; ACC), a key enzyme involved in fatty acid biosynthesis. It blocks apoptosis induced by the fatty acid synthase inhibitor C75 (Prod. No. ALX-270-286) and stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.

Product Details

Alternative Name:5-(Tetradecyloxy)-2-furoic acid, RMI-14514
Purity:≥99% (TLC)
Appearance:Off-white solid.
Solubility:Soluble in dimethyl formamide, DMSO (10mg/ml), 100% ethanol or methanol. Sparingly soluble in aqueous buffers.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools: P.K. Morgan, et al.; J. Biol. Chem. 297, 101341 (2021), Abstract;
Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function: J. K. Gardner, et al.; PLoS One 10, e0123563 (2015), Application(s): Cell Culture, Abstract; Full Text
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004), Abstract;
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells: W. Zhou, et al.; Cancer Res. 63, 7330 (2003), Abstract;
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res. 60, 213 (2000), Abstract;
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000), Abstract;
Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family: A. Schmidt, et al.; Mol. Cell. Endocrinol. 155, 51 (1999), Abstract;
Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster: C.M. Arbeeny, et al.; J. Lipid Res. 33, 843 (1992), Abstract;
Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid: D.L. Halvorson & S.A. McCune; Lipids 19, 851 (1984), Abstract;
Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver: N. Fukuda and J.A. Ontko; J. Lipid Res. 25, 831 (1984), Abstract;
5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids: R.A. Parker, et al.; J. Med. Chem. 20, 781 (1977), Abstract;

General Literature References

Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase: C. Forest, et al.; Biochem. Soc. 31, 1125 (2003), Abstract;
Hypothalamic malonyl-CoA as a mediator of feeding behavior: Z. Hu, et al.; PNAS 100, 12624 (2003), Abstract;
Mechanistic diversity and regulation of Type II fatty acid synthesis: H. Marrakchi, et al; Biochem. Soc. Trans. 30, 1050 (2002), Abstract;

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