A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.
Product Details
| Formula: | C14H14O4S2 |
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| MW: | 310.4 |
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| CAS: | 93718-83-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange crystalline solid. |
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| Solubility: | Soluble in DMSO (50mM) or ethanol (5mM). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors: J. S. Lazo, et al.; Mol. Pharmacol.
61, 720 (2002),
Abstract;
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