Replaces Prod. #: ALX-270-339
Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.
Product Details
| Alternative Name: | Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone |
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| Formula: | C14H8N2O |
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| MW: | 220.2 |
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| CAS: | 129-56-6 |
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| RTECS: | CB4585000 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow to brown solid. |
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| Solubility: | Soluble in DMSO or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Technical Info/Product Notes: | Note: Product is not sterile.
Replacement for ADI-HPK-111. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Regulators of thymic stromal lymphopoietin production by human adipocytes: L. Ma, et al.; Cytokine
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The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties: K. Oniki, et al.; Sci. Rep.
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Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells: Y. Hosokawa, et al.; Inflammation
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Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice: W. Nemoto, et al.; Neuropharmacology
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Full Text
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep.
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Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells: E. Roggli, et al.; Diabetologia
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CpG Protects Human Monocytic Cells against HIV-Vpr-Induced Apoptosis by Cellular Inhibitor of Apoptosis-2 through the Calcium-Activated JNK Pathway in a TLR9-Independent Manner: M. Saxena, et al.; J. Immunol.
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Mechanism and Repertoire of ASC-Mediated Gene Expression: M. Hasegawa, et al.; J. Immunol.
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Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol.
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Full Text
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