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Jnk inhibitor
BML-EI305-0010 10 mg 89.00 USD
BML-EI305-0050 50 mg 373.00 USD
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Replaces Prod. #: ALX-270-339

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Product Details

Alternative Name:Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
Purity:≥98% (TLC)
Appearance:Yellow to brown solid.
Solubility:Soluble in DMSO or methanol.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light. Keep under inert gas.
Technical Info/Product Notes:Note: Product is not sterile.
Replacement for ADI-HPK-111.
Regulatory Status:RUO - Research Use Only
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Product Literature References

CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells: K. Franke, et al.; Int. J. Mol. Sci. 24, 4135 (2023), Abstract;
Picolinafen exposure induces ROS accumulation and calcium depletion, leading to apoptosis in porcine embryonic trophectoderm and uterine luminal epithelial cells: W. Park, et al.; Theriogenology 201, 12 (2023), Abstract;
Aclonifen induces bovine mammary gland epithelial cell death by disrupting calcium homeostasis and inducing ROS production: J. Park, et al.; Pestic. Biochem. Physiol. 181, 105011 (2022), Abstract;
Effect of Antioxidants on the Production of MCP-1 Chemokine by EA. hy926 Cells in Response to IL-6: M.A. Chelombitko, et al.; Moscow Univ. Biol. Sci. Bull. 77, 184 (2022), Abstract;
Effects of S-PRG filler eluate on MMP-1 and MMP-3 secretion by human gingival fibroblasts: H. Inoue, et al.; Dent. Mater. J. 41, 159 (2022), Abstract;
Exosomal p38 Mitogen-activated Protein Kinase Promotes Tumour Repopulation in TP53-mutated Bile Duct Cancer Cells: M. Osawa, et al.; Anticancer Res. 42, 745 (2022), Abstract;
Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure: N. Gehrke, et al.; Cell Death Dis. 13, 510 (2022), Abstract;
Inhibition of thymic stromal lymphopoietin production by FK3453: R. Segawa, et al.; J. Pharmacol. Sci. 149, 198 (2022), Abstract;
Diflubenzuron leads to apoptotic cell death through ROS generation and mitochondrial dysfunction in bovine mammary epithelial cells: W. Lee, et al.; Pestic. Biochem. Physiol. 177, 104893 (2021), Abstract;
Exposure to fipronil induces cell cycle arrest, DNA damage, and apoptosis in porcine trophectoderm and endometrial epithelium, leading to implantation defects during early pregnancy: W. Park, et al.; Environ. Pollut. 291, 118234 (2021), Abstract;
FJU-C28 inhibits the endotoxin-induced pro-inflammatory cytokines expression via suppressing JNK, p38 MAPK and NF-κB signaling pathways: F. Jung, et al.; Pharmacol. Res. Perspect. 9, e00876 (2021), Abstract;
Fluroxypyr-1-methylheptyl ester causes apoptosis of bovine mammary gland epithelial cells by regulating PI3K and MAPK signaling pathways and endoplasmic reticulum stress: G. Am, et al.; Pestic. Biochem. Physiol. 180, 105003 (2021), Abstract;
How CD40L Reverse Signaling Regulates Axon and Dendrite Growth: P. Carriba & A.M. Davies; Cell. Mol. Life Sci. 78, 1065 (2021), Abstract; Full Text
Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes: S.P. Ng, et al.; Biochem. Biophys. Rep. 28, 101127 (2021), Abstract;
Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: K. Min, et al.; Cancers (Basel) 12, 3388 (2020), Abstract; Full Text
Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract; Full Text
Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells: J.H. Yen, et al.; Cells 9, 877 (2020), Abstract; Full Text
Regulators of thymic stromal lymphopoietin production by human adipocytes: L. Ma, et al.; Cytokine 136, 155284 (2020), Application(s): Treatment of preadipocytes in culture supernatant, Abstract;
The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties: K. Oniki, et al.; Sci. Rep. 10, 5973 (2020), Abstract; Full Text
Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells: C. Yang, et al.; Mol. Hum. Reprod. 25, 755 (2019), Abstract;
Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells: V. Fleskens, et al.; Cell Rep. 26, 3600 (2019), Abstract; Full Text
Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction: S. Ryu, et al.; J. Cell. Biochem. 120, 17449 (2019), Abstract;
Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells: C.W. Lee, et al.; Redox Biol. 18, 93 (2018), Abstract; Full Text
Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction: W. Lim, et al.; J. Cell. Physiol. 233, 3129 (2018), Abstract;
Fibroblast growth factor 2 induces proliferation and distribution of G2 /M phase of bovine endometrial cells involving activation of PI3K/AKT and MAPK cell signaling and prevention of effects of ER stress: W. Lim, et al.; J. Cell. Physiol. 233, 3295 (2018), Abstract;
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice: J.H. Choi, et al.; Exp. Mol. Med. 50, 111 (2018), Abstract;
Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrialdysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation: S. Park, et al.; J. Cell. Physiol. 233, 8597 (2018), Application(s): Treatment of ovarian cancer cells (ES2 and OV90), Abstract;
Differential expression and functional roles of chemokine (C-C motif) ligand 23 and its receptor chemokine (C-C motif) receptor type 1 in the uterine endometrium during early pregnancy in pigs: W. Jeong, et al.; Dev. Comp. Immunol. 76, 316 (2017), Abstract;
Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis: K. Hu, et al.; Cell Death Dis. 8, e2637 (2017), Abstract; Full Text
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells: Y. Hosokawa, et al.; Inflammation 40, 360 (2017), Abstract;
Myricetin suppresses invasion and promotes cell death in human placental choriocarcinoma cells through induction of oxidative stress: C. Yang, et al.; Cancer Lett. 399, 10 (2017), Abstract;
Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation: M.C. Gómez-Puerto, et al.; Autophagy 12, 1804 (2016), Abstract; Full Text
Calcitonin gene-related peptide is a key factor in the homing of transplanted human MSCs to sites of spinal cord injury: Y. Zhang, et al.; Sci. Rep. 6, 27724 (2016), Application(s): Migration assay in Boyden chamber, Abstract; Full Text
Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine 11, 2907 (2016), Application(s): Cell treatment to see effect on PM-induced phosphorylation, Abstract; Full Text
Hypotonic Stress-Induced Down-Regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-Dependent Endocytosis in Renal Tubular Epithelial Cells: N. Fujii, et al.; J. Biol. Chem. 291, 24787 (2016), Application(s):, Abstract; Full Text
NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism: T. Elmetwali, et al.; Cell Death Dis. 7, e2146 (2016), Application(s): Cell culture, Abstract;
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells: N. Hwang, et al.; Korean J. Ophthalmol. 30, 468 (2016), Abstract; Full Text
Amphiregulin may be a new biomarker of classically activated macrophages: C. Meng, et al.; Biochem. Biophys. Res. Commun. 466, 393 (2015), Application(s): Cell Culture, Abstract;
Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation: L. Ji, et al.; Biochim. Biophys. Acta. 1850, 750 (2015), Application(s): Cell Culture, Abstract;
CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells: Q. Shi, et al.; Genes Cancer 6, 220 (2015), Application(s): Cell Culture, Abstract; Full Text
Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells: W. Qi, et al.; Mol. Cell. Endocrinol. 405, 74 (2015), Application(s): Cell Culture, Abstract;
Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons: Z. Cao, et al.; Mar. Drugs 13, 903 (2015), Application(s): Cell Culture, Abstract; Full Text
Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice: W. Nemoto, et al.; Neuropharmacology 99, 221 (2015), Application(s): Injection into mice, Abstract;
Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes: W.C. Huang, et al.; Int. Immunopharmacol. 27, 32 (2015), Application(s): Cell Culture, Western Blot, Abstract;
Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling: Y.T. Oh, et al.; Oncotarget 6, 41324 (2015), Application(s): Cell culture , Abstract; Full Text
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep. 32, 513 (2014), Abstract; Full Text
Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells: E. Roggli, et al.; Diabetologia 55, 1699 (2012), Application(s): Treatment of pancreatic beta cells, Abstract;
CpG Protects Human Monocytic Cells against HIV-Vpr-Induced Apoptosis by Cellular Inhibitor of Apoptosis-2 through the Calcium-Activated JNK Pathway in a TLR9-Independent Manner: M. Saxena, et al.; J. Immunol. 187, 5865 (2011), Application(s): WB of human monocytes, Abstract; Full Text
Mechanism and Repertoire of ASC-Mediated Gene Expression: M. Hasegawa, et al.; J. Immunol. 182, 7655 (2009), Abstract;
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004), Abstract;
An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression: M. Shin, et al.; Biochim. Biophys. Acta 1589, 311 (2002), Abstract;
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis: Z. Han, et al.; J. Clin. Invest. 108, 73 (2001), Abstract; Full Text
Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes: G.G. Goss, et al.; Am. J. Physiol. Cell. Physiol. 281, C1978 (2001), Abstract;
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase: B.L. Bennett, et al.; PNAS 98, 13681 (2001), Abstract; Full Text
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells: B. Schnabl, et al.; Hepatology 34, 953 (2001), Abstract;

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