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BW B70C

Lipoxygenase inhibitor
 
BML-EI304-0005 5 mg 122.00 USD
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An orally available and biologically persistant inhibitor of 5-lipoxygenase. Blocks anaphylactic response in guinea pigs (2-50 mg/kg). Prevented LTC4 synthesis in macrophages and reduced leukocyte migration to the airways induced by endotoxin in guinea pigs at 0.1-1 mg/kg. Blocked IL-4 induced LTB4 production in monocytes.

Product Specification

Formula:C17H17FN2O3
 
MW:316.3
 
CAS:134470-38-5
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Lyprinol inhibits LTB4 production by human monocytes: B. Dugas, et al.; Allerg. Immunol. 32, 284 (2000), Abstract;
5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs: M.F. Bureau, et al.; Eur. J. Pharmacol. 324, 89 (1997), Abstract;
Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs: M. Yeadon, et al. ; Agents Actions 38, 8 (1993), Abstract;

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