An orally available and biologically persistant inhibitor of 5-lipoxygenase. Blocks anaphylactic response in guinea pigs (2-50 mg/kg). Prevented LTC4 synthesis in macrophages and reduced leukocyte migration to the airways induced by endotoxin in guinea pigs at 0.1-1 mg/kg. Blocked IL-4 induced LTB4 production in monocytes.
Product Details
| Formula: | C17H17FN2O3 |
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| MW: | 316.3 |
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| CAS: | 134470-38-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Lyprinol inhibits LTB4 production by human monocytes: B. Dugas, et al.; Allerg. Immunol.
32, 284 (2000),
Abstract;
5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs: M.F. Bureau, et al.; Eur. J. Pharmacol.
324, 89 (1997),
Abstract;
Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs: M. Yeadon, et al. ; Agents Actions
38, 8 (1993),
Abstract;
