Replaces Prod. #: ALX-270-037
A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).
Product Details
| Alternative Name: | Tyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline |
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| Formula: | C16H14N2O2 |
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| MW: | 266.3 |
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| CAS: | 146535-11-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white to brownish solid. |
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| Solubility: | Soluble in DMSO or dichloromethane. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2): F. Strutz, et al.; Kidney Int.
59, 579 (2001),
Abstract;
Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins: G.W. Krystal, et al.; Cancer Res.
57, 2203 (1997),
Abstract;
Full Text
Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296: M. Kovalenko, et al.; Biochemistry
36, 6260 (1997),
Abstract;
