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PDGF receptor tyrosine kinase inhibitor
BML-EI303-0005 5 mg 165.00 USD
BML-EI303-0025 25 mg 636.00 USD
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Replaces Prod. #: ALX-270-037

A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

Product Details

Alternative Name:Tyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline
Purity:≥98% (TLC)
Appearance:Off-white to brownish solid.
Solubility:Soluble in DMSO or dichloromethane.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling:Store tightly sealed in the dark. Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2): F. Strutz, et al.; Kidney Int. 59, 579 (2001), Abstract;
Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins: G.W. Krystal, et al.; Cancer Res. 57, 2203 (1997), Abstract; Full Text
Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296: M. Kovalenko, et al.; Biochemistry 36, 6260 (1997), Abstract;

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