PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7nM for PKCα and PKCβ; 6nM for PKCγ; 10nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCµ (IC50=20 µM) and therefore can be used to differentiate PKCµ from other isoforms.
Product Details
| Formula: | C26H26N4O3 |
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| MW: | 442.5 |
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| CAS: | 133053-19-7 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | Bright red solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Nitric oxide and N-acetylcysteine inhibit the activation of mitogen-activated protein kinases by angiotensin II in rat cardiac fibroblasts: D. Wang, et al.; J. Biol. Chem.
273, 33027 (1998),
Abstract;
Full Text
Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form: L. Stempka, et al.; J. Biol. Chem.
272, 6805 (1997),
Abstract;
Full Text
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes: M. Geschwendt, et al.; FEBS Lett.
392, 77 (1996),
Abstract;
